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In real-world settings, the association between GLP-1 RAs and the risk of psychiatric outcomes has yielded mixed findings

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Duzel, A

Its also why many protocols suggest administration before sleep, to align with and enhance the body's natural GH pulse during the night, turning this potential side effect into a synergistic benefit for sleep quality studies

doi:10.1093/aje/kwf018

Preclinical work in rodent models has demonstrated changes in synaptic markers and behavioral improvements on specific learning and memory assays, yet these findings are not directly transferable to humans